Not to be confused with sixth disease. See Exanthema subitum. Erythema infectiosum or fifth disease is one of several possible manifestations of infection by. Erythema infectiosum (fifth disease). Erythema infectiosum is a mild childhood disease that is caused by human parvovirus B This condition. A general overview of the symptoms, causes and treatment of fifth disease, and other useful tips for parents.

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Vitrakvi Vitrakvi larotrectinib is an oral selective tropomyosin receptor kinase TRK inhibitor for the treatment Joint involvement is usually diswase in the disease course as well. Update of the human parvovirus B19 biology.

Occasionally, the rash will extend over the bridge of the nose or around the mouth. Clear Turn Off Turn On. Chickenpox Herpes zoster Herpes zoster oticus Ophthalmic zoster Disseminated erythemw zoster Zoster-associated pain Modified varicella-like syndrome.

The rash may also have a lacy or reticular appearance as it starts to resolve.

Individuals with fifth disease are most infectious before the onset of symptoms. Adults who get it might also have joint pain and swelling.

When a patient has symptoms of arthralgias and exanthem, they are no longer contagious and are not at risk to spread the virus. The virus itself, or its viral DNA genetic mapalso can be detected in the blood of some patients.

Erythema, Infectiosum (Fifth Disease) – StatPearls – NCBI Bookshelf

Review Clinical presentations of parvovirus B19 infection. Instead, they may develop severe anemia not enough red blood cells as a result of being infected with parvovirus B Immunocompromised individuals typically do not show manifestations of rash and joint symptoms due to the belief that these are immune-mediated, and they would not have an adequate immune response to this infection for these symptoms to develop.


Children and adults with blood disorders sickle cell anemia, hemolytic anemiaand children who have cancer or an immune deficiency, are at increased risk of serious illness as a result of fifth disease. It can affects adults but less frequently.

Fifth disease – Wikipedia

Dsease with an immune deficiency may be given intravenous immunoglobulin IVIG that contains antibodies against parvovirus B Kids are not just little people. No specific therapy is recommended. Mediterr J Hematol Infect Dis. Fifth disease is transmitted primarily by respiratory secretions salivamucusetc.

Hirai Y, Takeda Y. This is a common illness found in the spring months and early summer months. IgM antibodies can usually be found within 7 to 10 days of virus exposure. Infection by parvovirus B19 destroys reticulocytes. Fifth Disease — see more articles. Macri A, Crane JS. Adolescents with joint pain may be treated with over-the-counter pain relievers such as acetaminophen Tylenol and others or ibuprofen AdvilMotrin and others.

Fifth Disease (Erythema Infectiosum)

Parvovirus B19 causes erythema infectiosum. Etiology Parvovirus B19 causes erythema infectiosum. Sean Kostolansky ; James R. Diagnosis of parvovirus B19 infection is usually not warranted due to the self-limiting progression of the disease and typical mild symptoms. Transmission can also occur via blood exposure. Call your doctor if you or your child develops a facial rash, especially if your child has a blood disorder or an immune deficiency, or is being treated for cancer.


The rash typically lasts a few days and may itch; some cases have been known to last for several weeks. During this time, most infected people don’t know that they are ill and capable of spreading their illness to others.

Since the virus is part of the grouping of egythema childhood illnesses, a child will be immune once the infection has run its course.

History and Physical The most common and classic presentation of erythema infectiosum is a mild febrile illness with rash. When To Call A Professional Call your doctor if idsease or your child develops a facial rash, especially if your child has a blood disorder or an immune deficiency, or is being treated for cancer.

If an immunocompetent host becomes infected, there can be a range of symptoms.

Understanding Fifth Disease (Erythema Infectiosum)

Although fifth disease in the mother usually does not threaten the unborn child, fifth disease in rare cases can cause miscarriage or fetal anemia. Testing can be obtained via bloodwork for specific antibodies.

Often, these patients will be much more ill-appearing with fevers, malaise, and eythema.